Question: Vesicular Trafficking a.How is a nascent transmembrane protein recognized for completion of its s…

Vesicular Trafficking

a.How is a
nascent transmembrane protein recognized for completion of its
synthesis and processing in the er/Golgi vesicular trafficking
pathway?

Who are the molecules
involved, and what are their functions with respect to this nascent
protein?

b.What are
the differences between COP I and COP II, and what destinations do
they help vesicles achieve in the er/Golgi vesicular trafficking
pathway?

c.Give a
detailed molecule and step by step account of the trafficking of a
protein from either:

i.The ER to
the cis-Golgi

ii.The
Trans-Golgi to the Lysosomes

d.If a
protein had the amino acid sequence KDEL in its structure, where is
its steady state location intended to be, and how is that steady
state location achieved?

e.What is
the role of rab GTPases in vesicular trafficking? When bound to GTP
and when bound to GDP?