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What is wrong with Mr. Haldol? You have been working at a health clinic as an aide for several months now and have seen how it operates. A patient is waiting for his appointment in the waiting room and is holding a paper bag and a large Starbucks coffee. You recognize him as Mavik Haldol, a 65 year old man who is about 15 kg overweight and suffers from a few common conditions for someone his age. You have spoken to him at past appointments so you know he was a smoker for 30 years but quit 5 years ago because he developed COPD. He comes to the clinic periodically for a number of different health problems. He does not look well today so you go over to him to ask how he is doing. He says that he is “OK” and proceeds to tell you that he has just retired and has been trying to stay healthy by walking regularly and eating lots of whole wheat products, salads, fruit cruciferous vegetables and juices (including pomegranate and grapefruit juice) because he has been having a hard time affording all of his medications as he does not have a good insurance plan. He also tells you that he is supposed to take Avandia (rosiglitazone) but can’t afford them so he does not take them. Then he says “My dietary changes do not seem to be working because I feel worse. I have had aches and pains in my muscles for the last few days. I think these pains may be because I am coming down with the flu. This is why I am at the clinic today”. He hands you the paper bag he was holding and you look in to discover it is full of his medications. He tells you that he is also taking an OTC decongestant. Sudafed, for some nasal congestion but did not bring it because he has just been taking it for a few days and it is not a prescription medication. You take a quick look at his medications and you politely say, “I will make sure the doctor knows about your medications and you walk out to the back of the clinic. Something does not feel right about Mr. Haldol’s situation. Your subconscious is trying to tell you something about his condition but you are not sure what. Try and solve the mystery of what is causing Mr. Haldol’s symptoms. His life is in your hands. The medications Mr. Haldol’s had in his bag are: Aspirin: 81 mg/day Atorvastatin (Lipitior) 40 mg/day Omeprazole (Prilosec) 40 mg/day Metformin (Glucophage) 500 mg/day Propranolol (Inderal) 200 mg/day Clorothiazide (Diuril) 500 mg/day Symbicort Turbuhaler 2 puffs/4 times a day Multivitamin, 1 a day Omega-3 oil capsule 2.300 mg capsules/twice a day (C) You think that Mr. Haldol’s muscle aches are a result of his medications. With the information you have been given and a bit of research on his medications, determine some of the likely causes of Mr. Haldol’s muscle pains. Could any of his medications or combination of medications cause his muscle soreness? If so, which ones and what are the interactions causing the effect (could it be the result of a drug-drug interaction, a drug-nutrient interaction or just an adverse effect of one of his medications? List all of the possibilities you found for this effect, given the information above (10 pts). (D) What do you think poor Mr. Haldol should do? He needs his medications but they seem to be causing some issues. Should he stop eating healthy foods or stop taking his medications and continue to eat healthy and exercise? What other health risks are there for Mr. Haldol if he continues to take all of these medications? Discuss how we can help Mr. Haldol by altering either his lifestyle or his medications (10 pts).
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