Question: Whereas the cholera toxin ADP-ribosylates the α subunit of
stimulatory G protein (Gs), thereby bl…
Whereas the cholera toxin ADP-ribosylates the α subunit of
stimulatory G protein (Gs), thereby blocking GTP
hydrolysis, pertussis toxin ADP-ribosylates the α subunit of
inhibitory G protein (Gi) and prevents interaction with
the receptor. What is the effect of these toxins on the
concentration of intracellular cAMP?
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Cholera toxin tends to increase cAMP |
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Cholera toxin tends to decrease cAMP concentration, whereas |
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They both tend to increase cAMP concentration. |
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They both tend to decrease cAMP concentration. |
